Concussion Assessment, Research and Education (CARE) Consortium
Mild traumatic brain injury (TBI) and sport-related concussion (SRC) are major public health problems. Although significant advances have been made in our understanding of concussion, to date, the natural history of concussion remains poorly defined, no objective biomarker of physiological recovery exists for clinical use, and athlete knowledge of the injury remains low. This investigation is poised to address the true natural history of clinical and physiological recovery of SRC, which has critical implications for improving safety, injury prevention, and medical care in athletes and military personnel. Objective: In keeping with the identified priorities of the National Collegiate Atheletic Association (NCAA) and Department of Defense (DoD), we propose the Concussion Assessment, Research and Education (CARE) Consortium as a scientific and operational framework for the NCAA-DoD Grand Alliance. Hypotheses: There are two over-arching hypotheses driving this proposal:(1) Neurophysiological recovery from concussion extends beyond clinical signs and symptoms resolution.(2) A multidimensional combination of biomechanical, genetic, neuroradiological, biological, and clinical variables will be more strongly predictive of concussion risk and recovery than any single predictor variable. This study led by the Indiana University School of Medicine, Medical College of Wisconsin, and University of Michigan marks what is considered to be the most comprehensive investigation of sport-related concussion (SRC) ever conducted. This study will allow scientists to better understand the true natural history of concussion in athletes and investigate the correlation between multi-dimensional predictor and outcome variables associated with SRC from a fully neurobiopsychosocial perspective in a common injured sample and single study design.
|Number of Subjects||34,583|