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Data Repository
Data repository is unknown. Contact the manager to learn where to access the data.
Study Enrollment
Added on Portal
Sep 28, 2016

Part of NNDC



NNDC established the rTMS Registry (rTMS) in 2011 and collected data through the end of 2014.  The goals of the study were three-fold:
  1. characterize the variation in rTMS therapy in regular clinical practice
  2. measure response and remission rates
  3. explore moderators of treatment response

Treatment was determined naturalistically. Subjects were recruited from patients who had sought clinical treatment with TMS in one of the nine NNDC participating centers. Eligibility criteria were minimal to encourage a sample representative of standard clinical practice in a tertiary care center:
  1. receiving rTMS for their depressive disorder, as determined by their attending psychiatrist
  2. at least 18 years of age
  3. literate in English
  4. without a diagnosis of schizophrenia or schizoffective disorder
  5. no contra-indications to receiving rTMS.

Standard measures were used to track outcome, including the following self-report measures:
  1. Patient Health Questionnaire-9 (PHQ-9) - a 9-item depression symptom severity scale
  2. Quick Inventory of Depressive Symptomatology - Self-Report (QIDS-SR): a 16-item patient self report measure which assesses the 9 DSM-IV symptom criteria for a major depressive episode
  3. Work and Social Adjustment Scale (WSAS): a 5-item scale assessing the impact of the patient’s symptoms on work and home life
  4. Generalized Anxiety Disorder Assessment (GAD-7): a 7-item scale assessing the degree of anxiety experienced by the patient;
  5. Adverse Childhood Experiences (ACE): a 10-item self-report scale assessing potentially traumatic experiences during childhood. Patients also completed a 10-point pain intensity rating, and the Columbia Suicide Severity Rating Scale, adapted for self-report.

Clinicians completed the Clinical Global Impression scale (CGI; severity, CGI-S, and change, CGI-I), single-item global ratings of severity and improvement with treatment. The registry was designed to acquire ratings at the initiation of rTMS treatment, and then for every week thereafter for the course of treatment. The PHQ-9, QIDS-SR and CGI scales were identified as primary outcome measures. Information about diagnosis, prior treatment and treatment response was based on the clinician’s interview and best judgment.

The rTMS Data Set includes data on 60+ patients presenting with a depressive episode from 9 participating NNDC Centers of Excellence.
Lead Scientist
John Greden and Pat Rinvelt, National Network of Depression Centers
Study Website
Meta Data
Number of Subjects 76
Primary Diagnoses
  • Depression
Species Human
  • Demographics, patient history or other descriptive data
  • Neurobehavioral or other outcome assessments
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